U-hGH ASSAY IN LARON DWARFISM
نویسندگان
چکیده
منابع مشابه
Early Investigations: Characterizations of the Circulating Growth Hormone
Identification of patients who resembled GH deficiency, both clinically (dwarfism, obesity) and biochemically (tendency for hypoglycemia) (Fig. 2.1), and high FFA (Fig. 2.2), but who had abnormally high overnight fasting serum concentrations of circulating hGH (Laron and Mannheimer 1966; Laron et al. 1968; Laron 1984) (Fig. 2.3), led us to conclude that we had discovered a new disease entity (L...
متن کاملImmunofunctional assay of human growth hormone (hGH) in serum: a possible consensus for quantitative hGH measurement.
Confirmation of the diagnosis of GH deficiency in adults and children involves provocative testing for human (h) GH. Different commercially available immunoassays yield largely discrepant results in the measurement of GH levels in human serum. These discrepancies result in doubtful relevance of cut-off levels proposed for GH provocative testing. We have developed an immunofunctional assay metho...
متن کاملLaron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouse.
Mice deficient in hepatocyte nuclear factor 1 alpha (HNF-1alpha) were produced by use of the Cre-loxP recombination system. HNF-1alpha-null mice are viable but sterile and exhibit a phenotype reminiscent of both Laron-type dwarfism and non-insulin-dependent diabetes mellitus (NIDDM). In contrast to an earlier HNF-1alpha-null mouse line that had been produced by use of standard gene disruption m...
متن کاملAnalytical validation of the Liaison hGH assay (DiaSorin)
Introduction Determination of the circulating growth hormone (GH) concentrations is an important tool in the diagnosis and monitoring of different pathologies, such as acromegaly and GH deficiency. However, GH determination is challenging. Indeed, the discrepancies observed between the different commercially available immunoassays represent a critical problem and have led to an important confus...
متن کاملAntibodies to Human Growth Hormone (hgh) in Human Subjects Treated with Hgh.
Human growth hormone (HGH) (1, 2) has been used experimentally and therapeutically in man since 1957 (3-5). The metabolic and growth-promoting effects of the parenterally administered hormone in humans (3-5) and the antigenicity of various HGH preparations in rabbits and in guinea pigs (6, 7) are well documented. This paper describes the appearance of specific antibodiesto HGH in the plasma of ...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1993
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-199305001-00210